Check out the article from Prof. Michael Zaworotko, SSPC Co Director and Bernal Chair of Crystal Engineering et al. here on a new Werner complex that exhibits switching behaviour between non-porous (apohost) and porous (guest-loaded) phases upon exposure to o-xylene but not when exposed to other C8 isomers. High o-xylene selectivity (>6) vs. the other C8 isomers was observed from binary mixtures, only the third occurrence across all sorbent types.
Insights into Flow and Continuous Systems in Pharmaceutical Manufacturing: Challenges and Opportunities
Ireland’s pharmaceutical sector has transformed over the past 50 years, from an API manufacturing base to a global hub for high value activities including process R&D, formulation, bioprocessing, and biotechnology. A major recent shift has been the adoption of continuous flow technology, offering improvements in safety, efficiency, and flexibility. While integrating flow into a highly regulated environment is complex, Ireland’s ecosystem, multinational API sites, CDMOs, and innovative indigenous companies, has successfully advanced large scale API and RSM manufacture through strong collaboration with regulatory agencies. This commentary highlights key factors enabling this transition and the current state of continuous flow in API/RSM production.
https://doi.org/10.1021/acs.oprd.5c00309
Partners: Eli Lilly, MSD, Pfizer, JnJ, sk biotek, apc, almac, WAB, arran chemical, UCC, UCD, UL.
